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Table 7 Comparison of respiratory support parameters, breastfeeding outcomes, and length of stay

From: Transforming neonatal nursing: a randomized controlled trial comparing kangaroo care and standard protocols for survival in preterm infants with respiratory distress syndrome

Outcome measure

KMC group (n = 120)

Standard care group (n = 120)

Mean difference or RR (95% CI)

Effect size

p-value

Respiratory support

- Days on CPAP², Mean (SD)

3.2 (1.4) [1]³

5.4 (1.8) [2]

−2.2 (−2.6, − 1.8)**

1.36

<0.001

- Maximum FiO₂ required (%)

28.4 (5.2) [1]

34.6 (6.1) [1]

−6.2 (−7.7, − 4.7)**

1.09

<0.001

- Duration of O₂ support (days)

4.8 (2.1) [2]

7.2 (2.4) [1]

−2.4 (−3.0, − 1.8)**

1.07

<0.001

Breastfeeding outcomes⁴

- Initiation within 24 h, n (%)

98 (81.7) [1]

72 (60.0) [2]

1.36 (1.15–1.61)**

4.6 (3.2–8.4)

<0.001

- Exclusive at discharge, n (%)

89 (74.2) [2]

58 (48.3) [1]

1.53 (1.24–1.89)**

3.9 (2.8–6.7)

<0.001

- Continuation at 1 month, n (%)

82 (68.3) [1]

51 (42.5) [2]

1.61 (1.27–2.04)**

3.9 (2.7–7.1)

<0.001

Hospital course

- Length of stay (days), mean (SD)

18.4 (5.2) [1]

24.6 (6.1) [2]

−6.2 (−7.6, − 4.8)**

1.09

<0.001

- Early discharge⁶, n (%)

72 (60.0) [1]

45 (37.5) [1]

1.60 (1.22–2.10)**

4.4

<0.001

- Readmission rate, n (%)

4 (3.3) [0]

11 (9.2) [1]

0.36 (0.12–1.10)

N/A

0.064

Time to milestone achievement (days)

- Full oral feeds

12.3 (3.2) [1]

16.8 (3.8) [2]

−4.5 (−5.4, − 3.6)**

1.28

<0.001

- Temperature stability

4.2 (1.4) [1]

6.8 (1.8) [1]

−2.6 (−3.0, − 2.2)**

1.62

<0.001

- Weight Gain > 15 g/kg/day

5.8 (1.6) [2]

8.4 (2.1) [1]

−2.6 (−3.1, − 2.1)**

1.39

<0.001

  1. KMC Kangaroo mother care; CI confidence interval; RR relative risk; SD standard deviation; FiO₂ fraction of inspired oxygen; NNT number needed to treat; N/A not applicable
  2. 1Statistical tests: Student’s t-test for continuous variables, Chi-square test for categorical variables
  3. ²CPAP Continuous Positive Airway Pressure
  4. ³Numbers in square brackets [n] indicate missing data
  5. ⁴As defined by WHO criteria for exclusive breastfeeding
  6. NNT number needed to treat
  7. ⁶Defined as discharge before day 21 of life ** p < 0.001
  8. Abbreviations: KMC = Kangaroo Mother Care; CI = Confidence Interval; RR = Relative Risk; SD = Standard Deviation; FiO2 = Fraction of Inspired Oxygen; NNT = Number Needed to Treat; N/A = Not Applicable