Outcome variable | KMC group (n = 120) | Standard care group (n = 120) | Relative risk (95% CI) | Number needed to treat | p-value |
---|---|---|---|---|---|
Nosocomial infections | |||||
- Late-onset sepsis, n (%) | 8 (6.7) [1] | 20 (16.7) [1] | 0.40 (0.19–0.85)* | 10.0 (6.2–31.8) | 0.014 |
- Pneumonia, n (%) | 6 (5.0) [0] | 15 (12.5) [2] | 0.40 (0.16–0.98)* | 14.3 (7.5–91.6) | 0.042 |
- Necrotizing enterocolitis (NEC), n (%) | 10 (8.3) [1] | 25 (20.8) [1] | 0.40 (0.21–0.78)** | 8.3 (5.4–21.7) | 0.006 |
- Any infection, n (%) | 18 (15.0) [0] | 40 (33.3) [0] | 0.45 (0.27–0.75)** | 6.3 (4.2–12.1) | <0.001 |
Clinical parameters | |||||
- Days of antibiotics, mean (SD) | 5.0 (2.5) [1] | 8.2 (3.1) [2] | −3.2 (−3.9, − 2.5)** | 1.10 | <0.001 |
- Temperature instability, n (%) | 12 (10.0) [0] | 30 (25.0) [1] | 0.40 (0.22–0.72)** | N/A | 0.004 |
- Feeding intolerance, n (%) | 15 (12.5) [1] | 35 (29.2) [0] | 0.43 (0.25–0.73)** | N/A | 0.002 |
- Apnea episodes, n (%) | 10 (8.3) [0] | 25 (20.8) [1] | 0.40 (0.21–0.76)** | N/A | 0.007 |
- Hospital course | |||||
- Length of stay (days), mean (SD) | 18.0 (5.0) [0] | 24.5 (6.0) [1] | −6.5 (−7.9, − 5.1)** | 1.15 | <0.001 |
- CPAP duration (days), mean (SD) | 3.0 (1.7) [1] | 5.0 (2.1) [0] | −2.0 (−2.5, − 1.5)** | 1.05 | <0.001 |
- Readmission rate, n (%) | 5 (4.2) [0] | 12 (10.0) [1] | 0.42 (0.15–1.13) | N/A | 0.068 |
Multivariate analysis | Â | Â | Adjusted odds ratio (95% CI) | Â | p-value |
- No KMC implementation |  |  | 2.70 (1.85–3.95)** |  | <0.001 |
- Birth weight < 1500 g |  |  | 2.00 (1.25–3.20)** |  | 0.004 |
- CPAP > 4 days |  |  | 1.80 (1.15–2.80)** |  | 0.007 |
- Delayed feeding |  |  | 1.75 (1.10–2.65)* |  | 0.016 |